Cyclosporine A in the TReatment of Interstitial Pneumonitis Associated With Sjogren's Syndrome | Drug: Cyclosporin A|Drug: Prednisone|Drug: Placebo|Drug: Calcium carbonate D | Phase 4 | Not yet recruiting | N/A | N/A | Mar-16 |
Effect of Pilocarpine in Patients With Xerostomia | Drug: Pilocarpine|Other: Spray without Pilocarpine | Phase 4 | Recruiting | Brazil | 1 | Jul-17 |
A Phase III Study of KCT-0809 in Dry Eye Patients With Sj̦gren's Syndrome | Drug: KCT-0809 ophthalmic solution|Drug: Placebo | Phase 3 | Recruiting | Japan | 1 | Jun-17 |
A Long-term Study of KCT-0809 in Dry Eye Patients With Sj̦gren's Syndrome | Drug: KCT-0809 ophthalmic solution | Phase 3 | Recruiting | Japan | 1 | Apr-18 |
Efficacy and Safety of Abatacept in Patients With Primary Sj̦gren's Syndrome | Drug: Abatacept SC | Phase 3 | Recruiting | Netherlands | 1 | Feb-18 |
Laser Therapy to Treat the Dry Mouth of Sjogren's Syndrome | Device: Lasertherapy|Device: Sham Lasertherapy | Phase 3 | Recruiting | Brazil | 1 | Jun-16 |
Efficacy of Tocilizumab in Primary Sj̦gren's Syndrome. | Drug: Tocilizumab|Drug: Placebo | Phase 2|Phase 3 | Recruiting | France | 1 | Jan-17 |
Induction of Regulatory t Cells by Low Dose il2 in Autoimmune and Inflammatory Diseases | Drug: Interleukin 2 | Phase 2 | Recruiting | France | 10 | Jan-17 |
A Phase 2a, Randomized, Placebo Controlled, Study to Evaluate the Safety and Efficacy of AMG 557/MEDI5872 in Primary Sj̦gren's Syndrome | Biological: AMG 557/MEDI5872|Other: Placebo | Phase 2 | Recruiting | USA, Europe | 14 | Jul-17 |
UCB Proof of Concept Study in Patients With Primary Sjogren's Syndrome | Drug: UCB5857|Drug: Placebo | Phase 2 | Recruiting | Europe | 19 | Mar-17 |
Safety, Pharmacokinetics, and Preliminary Efficacy Study of CDZ173 in Patients With Primary Sj̦gren's Syndrome | Drug: CDZ173|Drug: Placebo | Phase 2 | Not yet recruiting | N/A | N/A | Dec-17 |
Safety and Efficacy Study of Subcutaneous Belimumab and Intravenous Rituximab Co-administration in Subjects With Primary Sjogren's Syndrome | Drug: Belimumab|Drug: Rituximab|Drug: Placebo belimumab|Drug: Placebo rituximab | Phase 2 | Recruiting | Canada, Europe | 29 | Oct-18 |
Induction of Regulatory t Cells by Low Dose il2 in Autoimmune and Inflammatory Diseases | Drug: Interleukin 2 | Phase 2 | Recruiting | France | 10 | Aug-18 |
Preventive Approach to Congenital Heart Block With Hydroxychloroquine | Drug: Hydroxychloroquine | Phase 2 | Recruiting | USA | 1 | Dec-18 |
Safety, Pharmacokinetics and Preliminary Efficacy Study of CFZ533 in Patients With Primary Sj̦gren's Syndrome | Drug: CFZ533 active - Cohort 1|Drug: CFZ533 placebo- Cohort 1|Drug: CFZ533 active - Cohort 2|Drug: CFZ533 placebo - Cohort 2 | Phase 2 | Recruiting | USA, Europe | 13 | Feb-17 |
A Phase II Study With Low-dose Recombinant Human IL-2 for the Treatment of Primary Sj̦gren's Syndrome | Drug: hrIL-2 active|Drug: hrIL-2 placebo | Phase 2 | Recruiting | China | 1 | Jun-16 |
Evaluation of the Efficacy and the Mechanism of Chinese Herbal Formula SS-1 for Sj̦gren's Syndrome | Drug: SS-1|Drug: Placebo | Phase 2 | Recruiting | Taiwan | 1 | Jul-16 |
Proof of Concept Study to Evaluate the Efficacy and Safety of BMS-931699 (Lulizumab) or BMS-986142 in Primary Sj̦gren's Syndrome | Drug: BMS-931699|Drug: BMS-986142|Drug: Placebo | Phase 2 | Recruiting | Worldwide | 40 | Sep-18 |
A Study to Assess the Efficacy of RO5459072 in Participants With Primary Sjogren's Syndrome | Drug: Matching Placebo|Drug: RO5459072 | Phase 2 | Recruiting | USA, Europe | 32 | Jun-17 |
Modulation of Immunity-related Gene Expression Under the Chinese Herbal Formula SS-1 Treatment for Sj̦gren's Syndrome | Drug: SS-1|Drug: Placebo | Phase 2 | Recruiting | Taiwan | 2 | Oct-16 |
Acupuncture for Primary Sj̦gren Syndrome | Device: acupuncture group|Device: Sham Acupuncture group | Phase 2 | Not yet recruiting | China | 1 | Mar-17 |
An 8-week Study to Evaluate Safety and Efficacy of Recombinant Human Nerve Growth Factor (rhNGF) Eye Drops Solution Versus Vehicle in Patients With Dry Eye | Drug: NGF
Other: Vehicle | Phase 2 | Recruiting | USA | 1 | Sep-17 |
Safety and Efficacy Study of Filgotinib, GS-9876 and Tirabrutinib in Adults With Active Sjogren's Syndrome | Drug: Filgotinib
Drug: GS-9876
Drug: Tirabrutinib
Drug: Filgotinib placebo
Drug: GS-9876 placebo
Drug: Tirabrutinib placebo | Phase 2 | Not yet recruiting | N/A | N/A | May-19 |
Safety and Efficacy of VAY736 in Patients With Primary Sjogren's Syndrome (pSS) | Biological: VAY736|Other: Placebo | Phase 2 | Not yet recruiting | USA, Europe | 4 | Sep-19 |
DNase Treatment for Dry Eyes | Drug: DNase|Drug: Vehicle | Phase 1|Phase 2 | Recruiting | USA | 1 | Mar-17 |
Blood Based Eyedrops From Different Sources in the Treatment of Severe Keratopathy | Other: CBS eyedrops
Other: PBS eyedrops | Phase 1|Phase 2 | Recruiting | Italy | 3 | Sep-17 |
Tear Solutions topical synthetic peptide treatment for dry eye | Drug: Lacripep | Phase 1|Phase 2 | Recruiting | USA | 27 | |
Study of Iguratimod in Sj̦gren's Syndrome | Drug: Iguratimod | Phase 1|Phase 2 | Recruiting | China | 1 | Feb-18 |
A PH I Pilot Imaging Study to Evaluate Molecular Imaging Methods in HVs and pSS Pts | Radiation: 18F-FDG PET/CT Imaging|Radiation: 11C-MET PET/CT Imaging|Procedure: MRI Imaging with intravenous contrast with gadoterate meglumine|Procedure: Minor Salivary gland (labial) biopsy | Phase 1 | Recruiting | UK | 3 | Aug-17 |
A Phase 1 Study of MEDI7734 in Type I Interferon-Mediated Autoimmune Diseases | Biological: MEDI7734|Biological: Placebo | Phase 1 | Recruiting | USA | 7 | Nov-17 |
A Study of LY3090106 in Participants With Sj̦gren's Syndrome (SS) | Drug: LY3090106|Drug: Placebo | Phase 1 | Recruiting | USA, Europe | 7 | Sep-17 |
Endoscopic Treatment of Salivary Glands Affected by Sj̦gren's Syndrome | Procedure: Sialoendoscopy|Drug: saline|Drug: hydrocortisone | | Recruiting | Netherlands | 1 | Dec-16 |
Prospective Maternal Surveillance of SSA (Sj̦gren Syndrome A) Positive Pregnancies Using a Hand-held Fetal Heart Rate Monitor | Observational | | Recruiting | USA | 1 | Dec-20 |
Rare Disease Patient Registry & Natural History Study - Coordination of Rare Diseases at Sanford | Observational | | Recruiting | USA | 1 | Dec-00 |
Exercise in Sjogren, Myositis and Takayasu's Arteritis | Other: Exercise training | | Recruiting | Brazil | 1 | Jul-16 |
The Research Registry for Neonatal Lupus | Other: No intervention; observational | | Recruiting | USA | 1 | Jan-20 |
the Effect of HCG Treatment as a Cardiovascular Disease Morbidity Factor in Sjogren Syndrome Patients | Other: Retrospective study | | Not yet recruiting | N/A | N/A | Apr-16 |
Characterization of Diseases With Salivary Gland Involvement | Observational | | Recruiting | USA | 1 | 1-Jan-25 |
Early Detection of Pulmonary- and Pulmonary Vascular Disease in Sj̦gren Syndrome | Observational | | Recruiting | Austria | 1 | Oct-17 |
Implantology and Sj̦gren's Syndrome | Device: Biohorizons Laser-lok bonelevel dental implants | | Recruiting | Netherlands | 5 | May-18 |
Pregnancy and Medically Assisted Conception in Rare Diseases | Observational | | Recruiting | France | 1 | Jun-19 |
Exploring Immune Cell Signatures in Autoimmunity and Dry Eye Syndrome | Other: Cross-sectional study | | Recruiting | Singapore | 1 | Apr-17 |
A Study of Flt3-Ligand Levels in Sj̦grens Syndrome | Observational | | Recruiting | Sweden | 1 | Jun-17 |
Be the Bridge Between Researchers and a Cure (GVHD, ALS, Hepatitis B, Alzheimer's Disease, Leukemia, and More) | Observational | | Recruiting | USA | 1 | Aug-20 |
Regulatory B Cells in Inflammatory Rheumatisms and Biomarkers of Response to Biologic Treatments | Observational | | Recruiting | France | 1 | Jul-16 |
Autoreactive Anti-Ro/SSA IgE To Determine Primary Sj̦gRen's Syndrome's Disease Activity | Other: Blood samples | | Not yet recruiting | France | 5 | Jun-24 |
Primary Sj̦gren Syndrome | Other: skin biopsy | | Recruiting | France | 7 | Sep-16 |
The ASSESS National Multi-center Prospective Cohort | Other: No intervention | | Recruiting | France | 1 | Sep-30 |
The Pathogenesis and Natural History of Sjogren s Syndrome | Observational | | Recruiting | USA | 1 | null |
Duke Autoimmunity in Pregnancy Registry | Observational | | Recruiting | USA | 1 | Dec-17 |
Ultrasound Elastography of Salivary Glands | Observational | | Recruiting | France | 1 | Aug-17 |
LAMELLEYE for the Treatment of Dry Eye Symptoms in pSS Patients | Device: LAMELLEYE
Device: OPTIVE FUSION | | Not yet recruiting | N/A | N/A | Jan-18 |