Sjogren’s Syndrome Clinical Trial Listing

Below, I have attempted to capture and maintain a list of current clinical trials that are relevant to SS patients. This information comes from open trials on clinicaltrials.gov. For some background on clinical trials, check out this post.

The table below can be sorted using the table column headers, and filtered on keywords across all columns.

Columns are as follows:

Trial Name – The supplied name of the clinical trial.
Recruitment – Recruitment status (Recruiting, Not yet recruiting).
Interventions – The treatment being offered. Trials without treatments are Observational.
Phases – Three phases are required for approval. Phase 3 trials are the final phase.
Locations – The countries or regions where the trial is conducted. Trials with more than two regions are Worldwide.
Sites – The number of different trial sites within the indicated locations.
End – The anticipated completion date for the trial.

If you notice any errors or missing trials, please let me know.

Trial Name	Interventions	Phases	Recruitment	Locations	Sites	End
Cyclosporine A in the TReatment of Interstitial Pneumonitis Associated With Sjogren's Syndrome	Drug: Cyclosporin A\|Drug: Prednisone\|Drug: Placebo\|Drug: Calcium carbonate D	Phase 4	Not yet recruiting	N/A	N/A	Mar-16
Effect of Pilocarpine in Patients With Xerostomia	Drug: Pilocarpine\|Other: Spray without Pilocarpine	Phase 4	Recruiting	Brazil	1	Jul-17
A Phase III Study of KCT-0809 in Dry Eye Patients With Sj̦gren's Syndrome	Drug: KCT-0809 ophthalmic solution\|Drug: Placebo	Phase 3	Recruiting	Japan	1	Jun-17
A Long-term Study of KCT-0809 in Dry Eye Patients With Sj̦gren's Syndrome	Drug: KCT-0809 ophthalmic solution	Phase 3	Recruiting	Japan	1	Apr-18
Efficacy and Safety of Abatacept in Patients With Primary Sj̦gren's Syndrome	Drug: Abatacept SC	Phase 3	Recruiting	Netherlands	1	Feb-18
Laser Therapy to Treat the Dry Mouth of Sjogren's Syndrome	Device: Lasertherapy\|Device: Sham Lasertherapy	Phase 3	Recruiting	Brazil	1	Jun-16
Efficacy of Tocilizumab in Primary Sj̦gren's Syndrome.	Drug: Tocilizumab\|Drug: Placebo	Phase 2\|Phase 3	Recruiting	France	1	Jan-17
Induction of Regulatory t Cells by Low Dose il2 in Autoimmune and Inflammatory Diseases	Drug: Interleukin 2	Phase 2	Recruiting	France	10	Jan-17
A Phase 2a, Randomized, Placebo Controlled, Study to Evaluate the Safety and Efficacy of AMG 557/MEDI5872 in Primary Sj̦gren's Syndrome	Biological: AMG 557/MEDI5872\|Other: Placebo	Phase 2	Recruiting	USA, Europe	14	Jul-17
UCB Proof of Concept Study in Patients With Primary Sjogren's Syndrome	Drug: UCB5857\|Drug: Placebo	Phase 2	Recruiting	Europe	19	Mar-17
Safety, Pharmacokinetics, and Preliminary Efficacy Study of CDZ173 in Patients With Primary Sj̦gren's Syndrome	Drug: CDZ173\|Drug: Placebo	Phase 2	Not yet recruiting	N/A	N/A	Dec-17
Safety and Efficacy Study of Subcutaneous Belimumab and Intravenous Rituximab Co-administration in Subjects With Primary Sjogren's Syndrome	Drug: Belimumab\|Drug: Rituximab\|Drug: Placebo belimumab\|Drug: Placebo rituximab	Phase 2	Recruiting	Canada, Europe	29	Oct-18
Induction of Regulatory t Cells by Low Dose il2 in Autoimmune and Inflammatory Diseases	Drug: Interleukin 2	Phase 2	Recruiting	France	10	Aug-18
Preventive Approach to Congenital Heart Block With Hydroxychloroquine	Drug: Hydroxychloroquine	Phase 2	Recruiting	USA	1	Dec-18
Safety, Pharmacokinetics and Preliminary Efficacy Study of CFZ533 in Patients With Primary Sj̦gren's Syndrome	Drug: CFZ533 active - Cohort 1\|Drug: CFZ533 placebo- Cohort 1\|Drug: CFZ533 active - Cohort 2\|Drug: CFZ533 placebo - Cohort 2	Phase 2	Recruiting	USA, Europe	13	Feb-17
A Phase II Study With Low-dose Recombinant Human IL-2 for the Treatment of Primary Sj̦gren's Syndrome	Drug: hrIL-2 active\|Drug: hrIL-2 placebo	Phase 2	Recruiting	China	1	Jun-16
Evaluation of the Efficacy and the Mechanism of Chinese Herbal Formula SS-1 for Sj̦gren's Syndrome	Drug: SS-1\|Drug: Placebo	Phase 2	Recruiting	Taiwan	1	Jul-16
Proof of Concept Study to Evaluate the Efficacy and Safety of BMS-931699 (Lulizumab) or BMS-986142 in Primary Sj̦gren's Syndrome	Drug: BMS-931699\|Drug: BMS-986142\|Drug: Placebo	Phase 2	Recruiting	Worldwide	40	Sep-18
A Study to Assess the Efficacy of RO5459072 in Participants With Primary Sjogren's Syndrome	Drug: Matching Placebo\|Drug: RO5459072	Phase 2	Recruiting	USA, Europe	32	Jun-17
Modulation of Immunity-related Gene Expression Under the Chinese Herbal Formula SS-1 Treatment for Sj̦gren's Syndrome	Drug: SS-1\|Drug: Placebo	Phase 2	Recruiting	Taiwan	2	Oct-16
Acupuncture for Primary Sj̦gren Syndrome	Device: acupuncture group\|Device: Sham Acupuncture group	Phase 2	Not yet recruiting	China	1	Mar-17
An 8-week Study to Evaluate Safety and Efficacy of Recombinant Human Nerve Growth Factor (rhNGF) Eye Drops Solution Versus Vehicle in Patients With Dry Eye	Drug: NGF Other: Vehicle	Phase 2	Recruiting	USA	1	Sep-17
Safety and Efficacy Study of Filgotinib, GS-9876 and Tirabrutinib in Adults With Active Sjogren's Syndrome	Drug: Filgotinib Drug: GS-9876 Drug: Tirabrutinib Drug: Filgotinib placebo Drug: GS-9876 placebo Drug: Tirabrutinib placebo	Phase 2	Not yet recruiting	N/A	N/A	May-19
Safety and Efficacy of VAY736 in Patients With Primary Sjogren's Syndrome (pSS)	Biological: VAY736\|Other: Placebo	Phase 2	Not yet recruiting	USA, Europe	4	Sep-19
DNase Treatment for Dry Eyes	Drug: DNase\|Drug: Vehicle	Phase 1\|Phase 2	Recruiting	USA	1	Mar-17
Blood Based Eyedrops From Different Sources in the Treatment of Severe Keratopathy	Other: CBS eyedrops Other: PBS eyedrops	Phase 1\|Phase 2	Recruiting	Italy	3	Sep-17
Tear Solutions topical synthetic peptide treatment for dry eye	Drug: Lacripep	Phase 1\|Phase 2	Recruiting	USA	27
Study of Iguratimod in Sj̦gren's Syndrome	Drug: Iguratimod	Phase 1\|Phase 2	Recruiting	China	1	Feb-18
A PH I Pilot Imaging Study to Evaluate Molecular Imaging Methods in HVs and pSS Pts	Radiation: 18F-FDG PET/CT Imaging\|Radiation: 11C-MET PET/CT Imaging\|Procedure: MRI Imaging with intravenous contrast with gadoterate meglumine\|Procedure: Minor Salivary gland (labial) biopsy	Phase 1	Recruiting	UK	3	Aug-17
A Phase 1 Study of MEDI7734 in Type I Interferon-Mediated Autoimmune Diseases	Biological: MEDI7734\|Biological: Placebo	Phase 1	Recruiting	USA	7	Nov-17
A Study of LY3090106 in Participants With Sj̦gren's Syndrome (SS)	Drug: LY3090106\|Drug: Placebo	Phase 1	Recruiting	USA, Europe	7	Sep-17
Endoscopic Treatment of Salivary Glands Affected by Sj̦gren's Syndrome	Procedure: Sialoendoscopy\|Drug: saline\|Drug: hydrocortisone		Recruiting	Netherlands	1	Dec-16
Prospective Maternal Surveillance of SSA (Sj̦gren Syndrome A) Positive Pregnancies Using a Hand-held Fetal Heart Rate Monitor	Observational		Recruiting	USA	1	Dec-20
Rare Disease Patient Registry & Natural History Study - Coordination of Rare Diseases at Sanford	Observational		Recruiting	USA	1	Dec-00
Exercise in Sjogren, Myositis and Takayasu's Arteritis	Other: Exercise training		Recruiting	Brazil	1	Jul-16
The Research Registry for Neonatal Lupus	Other: No intervention; observational		Recruiting	USA	1	Jan-20
the Effect of HCG Treatment as a Cardiovascular Disease Morbidity Factor in Sjogren Syndrome Patients	Other: Retrospective study		Not yet recruiting	N/A	N/A	Apr-16
Characterization of Diseases With Salivary Gland Involvement	Observational		Recruiting	USA	1	1-Jan-25
Early Detection of Pulmonary- and Pulmonary Vascular Disease in Sj̦gren Syndrome	Observational		Recruiting	Austria	1	Oct-17
Implantology and Sj̦gren's Syndrome	Device: Biohorizons Laser-lok bonelevel dental implants		Recruiting	Netherlands	5	May-18
Pregnancy and Medically Assisted Conception in Rare Diseases	Observational		Recruiting	France	1	Jun-19
Exploring Immune Cell Signatures in Autoimmunity and Dry Eye Syndrome	Other: Cross-sectional study		Recruiting	Singapore	1	Apr-17
A Study of Flt3-Ligand Levels in Sj̦grens Syndrome	Observational		Recruiting	Sweden	1	Jun-17
Be the Bridge Between Researchers and a Cure (GVHD, ALS, Hepatitis B, Alzheimer's Disease, Leukemia, and More)	Observational		Recruiting	USA	1	Aug-20
Regulatory B Cells in Inflammatory Rheumatisms and Biomarkers of Response to Biologic Treatments	Observational		Recruiting	France	1	Jul-16
Autoreactive Anti-Ro/SSA IgE To Determine Primary Sj̦gRen's Syndrome's Disease Activity	Other: Blood samples		Not yet recruiting	France	5	Jun-24
Primary Sj̦gren Syndrome	Other: skin biopsy		Recruiting	France	7	Sep-16
The ASSESS National Multi-center Prospective Cohort	Other: No intervention		Recruiting	France	1	Sep-30
The Pathogenesis and Natural History of Sjogren s Syndrome	Observational		Recruiting	USA	1	null
Duke Autoimmunity in Pregnancy Registry	Observational		Recruiting	USA	1	Dec-17
Ultrasound Elastography of Salivary Glands	Observational		Recruiting	France	1	Aug-17
LAMELLEYE for the Treatment of Dry Eye Symptoms in pSS Patients	Device: LAMELLEYE Device: OPTIVE FUSION		Not yet recruiting	N/A	N/A	Jan-18